task currently important.
Regulation of nanoparticles.
Size : 10~100nm (EPR effect)
Coating PEG polymer
Why nanoparticles?
1) It can deliver a larger quantity of drugs with better safety.
2) Easy to attach targeting ligands.
3) It is enough size to deliver multi-drugs.
4) Can regulate releasing of drug particles.
5) Can avoid multidrug resistance through cell-surface protein pump.
Theory
In general, preparation methods for nanoparticles make use of capping agents, such as surfactants, polymers or biomaterial, in order to confine the growth. Occasionally, the selective or preferential adsorption of capping agents onto particular crystallograp- hic facets during the growth stage permits diverse shapes to be produced, for example triangles, hexagons, disks, rods and multi
and biological properties that differ from those of their larger, or bulk counterparts
Nanotechnology: The National Nanotechnology Initiative(NNI)-> the science of materials and phenomena in the range of 1 to 100nm in diameter
*Features of ‘nanoparticles’
Size
Shape
Surface area
Permeability
ex) liposome, polymer, quantum dot, magnetic particle, carbon nanotube, nanoshell
1.Nano
어원 : 그리스어 ‘nanos’ – 난쟁이
SI 단위계에서 10-9
1 나노미터(nm): 10억분의 1m
Nanotechnology :
Research and technology development at the atomic, molecular, or macromolecular levels, in the length scale of approximately 1~100nm range
The medical application of nanotechnology
나노물질이 갖는 특유의 성질을 질병의 진단, 치료
nanoparticles that can carry the drug molecules to the target safely.
5.2.2 Nanocarriers - Nanoparticles
Before starting with the functionalization of nanoparticles, it is important to keep in mind a range of useful properties we wish to have in any drug delivery across the BBB(Blood brain barrier). In this context, owing to their small size, customizable surface, improved solubility, tar
The cathode electrocatalyst was the electrostatic adduct of bilirubin oxidase (BOD) also a polyanion at physiological pH
Carbon Nanotube-AttachedGlucose Oxidase for Biofuel Cells
The carbon electrode coated with CNT–GOx composites
was applied as an anode in a model glucose/O2 biofuel cell
CNT-supported glucose oxidase (CNT–GOx) was examined in the presence of 1,4
II. 본 론
1. Deliver drug로 사용되는 고분자의 종류와 특징
가. Chitosan/Poly -Glutamic acid(PGA)
(1) Chitosan과 PGA의 성질
- Chitosan은 tissue engineering, drug delivery 분야에서 가장 널리 적용되는 생체재료 중의 하나이다. chitin의 부분적인 탈 아세틸화에 의해 제조되어진다. (그림 1)
그림 1 : (a) 키토산 (b) PGA 의
Potential bio-accumulation of nanoscale particles.
Accumulation of a substance within a species can occur due to lack of degradationor excretion
Many nanoparticles are not biodegradable.
If nanoparticles enter organisms low in the food web, they may be expected to accumulate in organisms higher in the food web.
Very little is understood about possible health
effects of nanoparti
Dip-pen Lithography
1. 서론
과학의 방향이 원자 크기대의 극소형의 것을 대상으로 하게 됨에 따라 이들을 관찰하고 조작하고 또 그 성질과 양을 이해하기 위해서는 나노 테크놀로지를 필요로 하게 되었다. 이러한 나노 테크놀로지는 1982년 스위스의 Binnig Rhorer 박사가 개발한 Scanning tunneling microscopy(STM
접착제용 폴리머의 대부분은 유기용매를 사용하는 폴리머가 주종을 이루며, 이들 유기용매를 사용한 폴리머는 용매 방출에 따른 환경오염이 심각하여, 현재 용매 방출에 대한 규제로 인해 접착제용 폴리머의 제조 기술의 전환이 요구되어 이에 부응한 수용성 폴리머에 대한 연구가 활발히 진행되고 있